Tylenol 8 Hour Arthritis Pain Reliever Extended-Release Caplets temporarily relieve the minor aches and pains of arthritis, including arthritic joint pain in hands, wrists, knees, ankles, elbows and feet. The first layer of the bi-layer design delivers fast-acting medicine for quick minor arthritic joint relief while the second has an extended release, offering effective pain relief that lasts up to 8 hours. With 650 milligrams of the pain-relieving and fever reducing ingredient acetaminophen per caplet, this pain medicine also temporarily relieves aches and pains associated with muscular aches, backache, premenstrual and menstrual cramps, the common cold, headache, and toothache. This effective oral pain reliever is gentle on your stomach, but tough on minor arthritic joint pain and also works as a fever reducer. Made by the #1 doctor recommended OTC brand for pain relief and fever reduction, it can be used by adults 18 years older and is safe when used as directed.